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Promising Molecule Drug aimed to treat cancer
The common aim for the majority of the biological scientists is to tackle Cancer. Cancer is a growing complication due to lifestyle changes like long exposure to the UV light, disrupted sleep cycles, stress, and pollution. Many people experience stress caused by their workload. For personal or professional reasons it is a common tendency to compromise sleep which results in a disrupted circadian rhythm. In simple words, circadian rhythm means the normal sleep cycle of human beings. In research named”Circadian Rhythm Disruption in Cancer Biology” conducted by Christos Savvudis and Micheal Koutsilieris, it is cited from the International Agency for Research on (IARC) 2007 that, “shiftwork that involves circadian disruption [as] probably carcinogenic to humans”. Therefore, the disruption in circadian rhythm is linked to the development of cancer in humans.
Nevertheless, the scientists at the University of Southern California have used the disrupted circadian rhythm as a tool to treat cancer. A disrupted body clock negatively affects the functioning of the normal cells. The same concept applies to the cancer cells. The researchers hypothesized that if the circadian clock of the cancer cells is disrupted it is possible to kill or at least hurt the cancer cells (“University”).
The scientists at the University of Southern California discovered a molecule named GO289 which interacts with a protein which regulates the circadian rhythm of the cells. This interaction also disrupts the four other proteins that are essential for cell growth and survival. These proteins are used by the cancer cells to develop; however, disrupting this cycle can potentially cease the metastasis or spread of cancer. “The GO289 can jam the cogs of the cell’s circadian clock, slowing its cycles. And it can do so with little impact to healthy cells” (“University”).
To test the efficiency of this new drug, “Go289” the researchers tested it on the human bone cells cancers. It was observed that the drug slowed the tumors; circadian clock. Additionally, it was tested on the human kidney cancer cells and the mice with acute myeloid leukemia. GO289 affected cancer cell metabolism and other circadian cycles that contributed to the growth of cancer.
The above photograph demonstrates the disrupted circadian rhythm of the human bone cancer cells caused by the drug molecule, GO289.
Works Cited:
The University of Southern California. (2019, January 23). Cancer has a biological clock and this drug may keep it from ticking: A promising drug slows cancer's circadian clock, halts its spread. ScienceDaily. Retrieved January 27, 2019, from www.sciencedaily.com/releases/2019/01/190123144524.htm
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